Clusters for multi target HANA replication

SAP is now allowing multi target replications. If I ahve a 4 system setup, A,B,C and D, where A and B are in one Region and C and D are in a different region on cloud. I have a cluster bet A and B and they are in HA. C and D are the DR systems. If I want to setup a SUSE cluster between C and D…can I do that? The HANA replication will be from A to B and A to C. Then from C to D. A to C is Asynch and C to D is SYNCH op mode of replication. Can somebody answer this for me. Thanks